The Buffalo Bulls aim for revenge on Tuesday evening. Buffalo lost to the Ohio Bobcats by a 45-24 margin in 2022, and the two teams meet again in a midweek MACtion tilt to begin Week 11 of the college football season. Buffalo is 3-6 overall this season, though the Bulls are 3-2 against MAC opponents. Ohio is 6-3 overall and 3-2 in the MAC to begin the 2023 campaign.

Kickoff is at 7:30 p.m. ET. The SportsLine consensus lists the Bobcats as 7-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest Ohio vs. Buffalo odds. Before making any Buffalo vs. Ohio picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio vs. Buffalo and just revealed its picks and MACtion predictions. You can visit SportsLine to see the model's CFB picks. Here are several college football odds and trends for Buffalo vs. Ohio: 

  • Ohio vs. Buffalo spread: Ohio -7
  • Ohio vs. Buffalo over/under: 44 points
  • Ohio vs. Buffalo money line: Ohio -279, Buffalo +225
  • OH: The Bobcats are 4-5 against the spread this season
  • BUFF: The Bulls are 5-4 against the spread this season
  • Ohio vs. Buffalo picks: See picks at SportsLine
  • Ohio vs. Buffalo live stream: fubo (try for free)

Why Ohio can cover

Ohio's defense is stout and also enters this week with a friendly matchup. The Bobcats are facing a Buffalo offense that is converting only 33.1% of third down chances this season, and the Bulls also have 11 interceptions. Buffalo is averaging fewer yards per pass attempt (5.3) than any MAC team, and the Bulls are near the bottom of the conference in completion rate (54.3%) and yards per rush attempt (3.7). 

For Ohio, Bryce Houston has the second-most tackles (93) in the MAC this season, and he leads a unit that leads the conference in scoring defense (15.7 points allowed per game) and total defense (264.6 total yards allowed per game). Ohio is No. 1 in the MAC in rushing yards allowed (93.2 per game) and yards allowed per rush attempt (3.3), and the Bobcats also make life difficult against opposing quarterbacks. Ohio has more interceptions (10) than passing touchdowns allowed (nine) this season, and opponents are averaging only 6.0 yards per pass attempt and 171.3 passing yards per game against the Bobcats. See which team to pick here.

Why Buffalo can cover

Buffalo's defense has found its footing in MAC play. The Bulls are allowing only 16.8 points per game to conference opponents and holding MAC foes to only 4.7 yards per play. Buffalo is giving up fewer than 150 passing yards per game and 5.4 yards per pass attempt in conference action, and no team is allowing fewer first downs per game (14.4) than Buffalo among MAC squads. 

Opponents are converting only 27.3% of third down chances against Buffalo in MAC games, and Devin Grant leads all MAC players with five interceptions in 2023. On offense, Buffalo quarterback Cole Snyder leads the conference with 1,683 passing yards this season, and he is also in the top three with 13 passing touchdowns. Snyder is coming off a 3,000-yard passing season in 2022, and he is flanked by senior running back Ron Cook Jr., who has 664 scrimmage yards and six touchdowns this season. See which team to pick here.

How to make Buffalo vs. Ohio picks

SportsLine's model is leaning Over on the total, projecting the teams to combine for 56 points. The model also says one side of the spread hits in well over 50% of simulations. You can see the model's picks at SportsLine.

So who wins Ohio vs. Buffalo, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Illinois spread you need to jump on, all from the model that has notched a profit of well over $2,000 on its top-rated college football spread picks, and find out.