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| The Eagles' A.J. Brown (hamstring) is questionable for Monday night's game against the Falcons after logging a limited practice Friday and sitting out Saturday's session altogether. The star wideout began feeling tightness in his hamstring during Friday's practice, and his absence Saturday was primarily the result of an abundance of caution. With Brown's game not until Monday night and soft-tissue injuries being unpredictable as they are, fantasy managers may consider another option if they have a reasonably talented alternative during Sunday's contests, especially since early Sunday reports indicate there is legitimate doubt as to Brown's availability. |
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| The Vikings' Jordan Addison (ankle) is out for Sunday's game against the 49ers after missing practice all week. In the talented second-year pro's absence, Brandon Powell, Jalen Nailor and perhaps even Trent Sherfield should have a chance to benefit with some extra targets, as could tight end Josh Oliver, who had a 2-27 line in Week 1. Meanwhile, Justin Jefferson could also see a slight bump in his already highly elevated involvement in Minnesota's air attack. |
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| The Bengals' Tee Higgins (hamstring) is doubtful for Sunday's game against the Chiefs after missing practice all week. In Higgins' likely absence, Andrei Iosivas, Trenton Irwin and Charlie Jones could serve as the No. 2-4 receivers, in that order, behind Ja'Marr Chase, who could be more prepared to capitalize on his teammate's absence this week after posting a 6-62 line in Week 1 following a very limited practice schedule in the months leading up to the opener. |
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| The Rams' Puka Nacua (knee) was placed on injured reserve Wednesday, sidelining him for the next four games at minimum. As per early Sunday reports, Nacua could actually miss between five and seven weeks with his PCL injury, as Los Angeles wants to ensure there are no further setbacks with an issue the second-year wideout initially began dealing with in training camp. For however long Nacua is out, the duo of Demarcus Robinson and Tyler Johnson, who combined for a 9-121 line against the Lions in Week 1 following Nacua's exit, will help pick up the slack behind No. 1 receiver Cooper Kupp beginning with Sunday's game against the Cardinals. |
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| The Bears' Keenan Allen (heel) is questionable for Sunday night's game against the Texans after missing practice all week. As per early Sunday reports, Allen will be tested in pregame warmups, and he's expected to be more limited than usual if he is able to garner active status. Rookie ninth overall pick Rome Odunze, who's expected to play through his knee injury, will be in line to pick more work under any circumstance and would fully move into the No. 2 role if Allen sits out. |
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| The Chiefs' Marquise Brown (shoulder) was placed on injured reserve Friday, sidelining him for the next four games at minimum. However, according to Saturday reports, Brown is not expected to play at all during the regular season following his scheduled Monday surgery for his sternoclavicular injury. As a result, rookie first-round pick Xavier Worthy, who scored both a rushing and receiving touchdown in his Week 1 NFL debut against the Ravens, should continue functioning as Kansas City's No. 2 receiver in Sunday's matchup against the Bengals. |
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| The Packers' Jayden Reed (calf) is questionable for Sunday's game against the Colts after putting in a limited practice Friday. As per early Sunday reports, Reed is expected to play after his stellar four-catch, 138-yard, one-touchdown tally through the air in Week 1 against the Eagles in Brazil, a performance that also included a 33-yard rushing score. However, Reed, who'd cede the No. 1 receiver job to Christian Watson if he took a turn for the worse, will be catching passes from Malik Willis, who'll start for Jordan Love (knee). |
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| The Bears' Rome Odunze (knee) is questionable for Sunday night's game against the Texans but managed to finish the week with a limited practice Friday. As per early Sunday reports, Odunze's status will be a true game-time decision, but he's expected to ultimately play. If he does suit up, the rookie, who finished with one catch for 11 yards on four targets in his NFL debut Week 1 against the Titans, would potentially play a quasi-No. 2 receiver role at worst, as teammate Keenan Allen (heel) is considered likely to be limited if he is able to play at all. |
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| The Lions' Jameson Williams (ankle) is questionable for Sunday's game against the Buccaneers after practicing in limited fashion all week. As per early Sunday reports, Williams is expected to play and attempt to build on the noteworthy five receptions for 121 yards and a touchdown on nine targets that he recorded in a season-opening overtime victory against the Rams. If Williams were to reverse course or have any setback, Kalif Raymond would be in line to move up to the No. 2 spot on the depth chart and also handle some of Williams' deep routes. |
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| The Chargers' Joshua Palmer (knee) is questionable for Sunday's game against the Panthers and missed Friday's practice after a pair of limited sessions to open the week. However, as per early Sunday reports, Palmer is trending toward playing, with a final decision likely to come down to pregame warmups. If he reverses course, Quentin Johnston would move up to the No. 2 spot on the Chargers' wide receiver depth chart. |
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| The Colts' Josh Downs (ankle) is questionable for Sunday's game against the Packers but was able to finish the week with a full Friday practice after back-to-back limited sessions Wednesday and Thursday. As per early Sunday reports, Downs is considered a true 50-50 proposition to play, and Indianapolis may ultimately err on the side of caution given the nature of high-ankle sprains. If Downs were to miss a second straight game to open the season, both rookie Adonai Mitchell and Alec Pierce, the latter having recorded a 3-125-1 line in Week 1, should be beneficiaries in the form of added targets from Anthony Richardson. |
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| The Broncos' Devaughn Vele (ribs) is out for Sunday's game against the Steelers after missing practice all week. In his confirmed absence, Marvin Mims should move into the No. 3 wide receiver role versus Pittsburgh. |
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| The Saints' A.T. Perry is off the injury report for Sunday's game against the Cowboys after practicing in full all week following a Week 1 absence due to a hand injury. Perry is expected to slide into the No. 4 receiver role in his season debut versus Dallas and begin his quest to build on the 12-246-2 line he generated across 10 regular-season games as a rookie in 2023. |
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| The Steelers' Roman Wilson (ankle) is questionable for Sunday's game against the Broncos after sandwiching a pair of limited practices around a full session Thursday. If Wilson sits out a second straight game to open his career, veteran Scotty Miller is slated to serve as Pittsburgh's No. 4 receiver. |
