The St. Louis Cardinals will look to extend their winning streak to three games when they take on the National League Central-rival Chicago Cubs on Friday in Chicago. The Cardinals (33-34), who have won three consecutive games against Chicago dating back to last season, are 16-19 on the road in 2024. The Cubs (33-36), who are 4-6 over the past 10 games, have played well at home, going 18-13 at Wrigley Field. St. Louis is 7-8 against NL Central foes, while Chicago is 8-15.

The game is slated to begin at 2:20 p.m. ET. The Cardinals are hitting .237 as a team this season, 19th-best in MLB, while the Cubs are batting .228, 26th-best. The Cubs are -123 favorites (risk $123 to win $100) on the money line in the latest Cardinals vs. Cubs odds from SportsLine consensus, while the over/under for total runs scored is 7.5. Before making any Cubs vs. Cardinals picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 12 of the 2024 MLB season on a 129-105 run on top-rated MLB picks dating back to last season, and it has excelled on top-rated run-line picks during that span, going 20-8 (+809). Anybody following has seen huge returns.

Now, the model has set its sights on Cubs vs. Cardinals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Cardinals vs. Cubs:

  • Cardinals vs. Cubs money line: Chicago -123, St. Louis +103
  • Cardinals vs. Cubs over/under: 7.5 runs
  • Cardinals vs. Cubs run line: Cubs -1.5 (+171)
  • STL: The Cardinals have hit the Under in 12 of their last 17 games (+7.50 units)
  • CHC: The Cubs have hit the team total Under in 28 of their last 43 games (+11.30 units)
  • Cardinals vs. Cubs picks: See picks at SportsLine

Why you should back the Cubs

Chicago is expected to send left-hander Jordan Wicks (1-2, 4.44 ERA) to the mound and the Cubs will look to get their offense going to help him. Right fielder Seiya Suzuki has three multi-hit games over the past six, including a 3-for-5 effort at Cincinnati on June 6 in an 8-4 loss. In that game, he doubled and scored a run. He was 2-for-4 with a walk and a homer in Wednesday's 4-3 win at Tampa Bay. In 43 games this season, Suzuki is batting .265 with eight doubles, one triple, eight homers, 26 RBI and 24 runs scored.

Infielder Michael Busch has swung a hot bat over the past six games, going 7-for-17 (.412) over that span, with two doubles. He was 2-for-3 in Wednesday's win at Tampa Bay. He was 2-for-3 with a double and one run scored in a 3-2 loss at Cincinnati on June 7. In 64 games this season, Busch is hitting .253 with 10 doubles, one triple, eight homers and 23 RBI. See which team to pick here.

Why you should back the Cardinals 

Right-hander Kyle Gibson (4-2, 3.76 ERA) will start for St. Louis. He is making his 14th start of the year, and has won his last three decisions. In his last outing, a no-decision in a 6-5 loss to Colorado, he pitched six innings, allowing eight hits, three earned runs and two walks, while striking out seven. He has allowed three or fewer earned runs in all but three games. He is looking for his first career win against the Cubs.

Helping power the Cardinals offense is shortstop Masyn Winn. A former second round pick by St. Louis in the 2020 MLB Draft, Winn is batting .302 with 12 doubles, three triples, three homers, 24 RBI and 23 runs scored. He was 2-for-4 with a triple and a run scored in Thursday's win over Pittsburgh. He has four multi-hit games over the past eight, including a 3-for-3 performance with a homer and two RBI in an 8-5 loss at Houston on June 4. In three games against Chicago this season, he is hitting .429 with a double and an RBI. See which team to pick here.

How to make Cardinals vs. Cubs picks

SportsLine's model is leaning Over on the total, projecting 10.1 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks and analysis at SportsLine.

So who wins Cubs vs. Cardinals, and which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that's 129-10 on top-rated MLB picks, and find out.