Teams trending in opposite directions clash on Sunday Night Baseball when the Chicago Cubs battle the St. Louis Cardinals in a key National League Central matchup. After Friday's game was rained out, St. Louis was able to outlast Chicago 7-6 on Saturday night. The Cubs (27-25), who have lost eight of 11, are 5-6 against division foes in 2024. The Cardinals (24-26), who have won six of seven, are just 2-6 against the NL Central so far this year.

First pitch from Busch Stadium in St. Louis is set for 7:10 p.m. ET. The Cubs lead the all-time series 1,210-1,176, but the Cardinals hold a 646-544 edge in home games. St. Louis is a -139 favorite on the money line (risk $139 to win $100) in the latest Cubs vs. Cardinals odds from SportsLine consensus, while the total number of runs Vegas thinks will be scored, or the over/under, is 8. Before making any Cardinals vs. Cubs picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 9 of the 2024 MLB season on a 123-99 run on top-rated MLB picks dating back to last season, and it has excelled on top-rated run-line picks during that span, going 20-8 (+708). Anybody following has seen huge returns.

Now, the model has set its sights on Cubs vs. Cardinals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Cardinals vs. Cubs:

  • Cubs vs. Cardinals money line: Chicago +118, St. Louis -139
  • Cubs vs. Cardinals over-under: 8 runs
  • Cubs vs. Cardinals run line: St. Louis -1.5 (+155)
  • CHC: The Cubs have hit the game total under in 27 of their last 45 games (+8.10 units)
  • STL: The Cardinals have hit the first five innings team total under in 22 of their last 35 games (+7.30 units)
  • Cubs vs. Cardinals picks: See picks at SportsLine

Why you should back the Cardinals

Shortstop Masyn Winn is among St. Louis' top hitters this season. In 45 games, he is batting .301 with 10 doubles, two triples, two homers and 13 RBI. He is on a 12-game hitting streak, including a 2-for-4 performance with one double and one RBI in Saturday's win. He was 2-for-4 with a double and a homer and two runs scored in a 5-4 win over the Baltimore Orioles in Game 2 of a doubleheader on Wednesday.

Also helping power the Cardinals is third baseman Nolan Arenado. Arenado was 1-for-4 with an RBI on Saturday. He has three multi-hit games over his past seven games, including a 2-for-4 effort with a double in Game 2 on Wednesday against the Orioles. He was 3-for-5 with an RBI in a 10-6 win over Boston on May 17. In 49 games this season, he is batting .268 with 10 doubles, three homers and 23 RBI. See which team to pick here

Why you should back the Cubs

Right-hander Javier Assad (4-0, 1.70 ERA) will start for Chicago. Assad has been dominant all season, having not allowed more than two earned runs in any of his 10 appearances. In a 7-1 win at Atlanta on May 15, he pitched six innings, allowing just four hits and one walk, while striking out seven. He also earned a win in a 5-0 victory over Milwaukee on May 5. In that game, he pitched six innings, allowing four hits and three walks, while striking out four.

Second baseman Nico Hoerner snapped a two-game hitless streak on Saturday, going 2-for-4 with a double, two RBI, and a run scored. He has 12 multi-hit performances on the year, including in a 6-5 win over the Brewers on May 4. In that game, he was 2-for-4 with a homer. In 45 games this season, he is hitting .263 with 12 doubles, one triple, two homers and 15 RBI. See which team to pick here

How to make Cubs vs. Cardinals picks

SportsLine's model is leaning Over on the total, projecting 9.2 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks and analysis at SportsLine.

So who wins Cardinals vs. Cubs, and which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that's 123-99 on top-rated MLB picks, and find out.