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USATSI

How detrimental can a QB1 injury be for a receiver's value in the NFL DFS lineups? Look no further than Tyreek Hill's and Jaylen Waddle's production since Tua Tagovailoa's injury. Hill went from the WR4 in Week 1 with Tagovailoa to WR57 and WR51 over the last two weeks without him. Waddle was the WR16 in Week 1 and WR60 AND WR57 over his last two games. Can daily Fantasy football players have any confidence in including either of these two top talents in Week 5 NFL DFS picks against the Patriots?

Conversely, a new quarterback has brought quality production out of Carolina's Diontae Johnson. The 28-year-old is averaging 7.5 receptions for 102.5 yards over his last two games with Andy Dalton at quarterback, compared to five receptions for 34 yards in two combined games with Bryce Young. Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine's NFL DFS lineup optimizer.

The DFS optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool. 

Now, SportsLine's NFL DFS optimizer has turned its attention to Sunday's 2024 NFL Week 5 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL Week 5 DFS picks for Sunday

One of the optimizer's top DFS value picks for Sunday is 49ers quarterback Brock Purdy ($6,200 on DraftKings, $7,700 on FanDuel). Purdy was the betting favorite late in the season last year to win NFL MVP before finishing fourth in the final voting. He was fifth in the NFL in passing yards (4,280) and third in touchdown passes (31). The 24-year-old led the NFL in yards per attempt (9.6) last season and leads the league in the category again this season (9.3) as he's surrounded by one of the best playmaking groups in the NFL.

Purdy has eight touchdowns and no interceptions in three career starts against the Cardinals, including throwing for 242 yards and four touchdowns in his most recent meeting with Arizona last season. The Cardinals are surrendering 26.5 points per game this season while allowing the second-most yards per pass (8.5) and highest completion percentage against (78.6%) in the NFL this season. With the 49ers averaging 39.3 points per game against Arizona with Purdy as the starter, the optimizer projects another huge performance from Purdy on Sunday. See who else to pick here.

The optimizer's NFL DFS strategy also includes rostering Packers wide receiver Jayden Reed ($6,500 on DraftKings, $7,200 on FanDuel). The Packers entered the season with one of the most exciting wide receiver rooms in the NFL, filled with young talent but still questions as to who would emerge as the true WR1. Reed has proven whenever he's on the field with Love this season he can be that guy. Reed has at least 138 yards in each of his two games with Love this season and is coming off seven receptions for 139 yards and a touchdown against the Vikings last week. He's a big-play threat with receptions of more than 40 yards in each contest.

The Packers will likely be without Christian Watson (doubtful, ankle). Romeo Doubs (personal) is questionable as Green Bay may be without two impactful receivers, leaving Reed to possibly generate an even larger target share than normal. He's averaging 19.8 yards per reception this season, so any time he has the ball in his hands, there's a chance for a huge play as he can provide value to NFL DFS lineups on Sunday against the Rams, who are allowing the second-most points (28.8) and yards (385.3) in the league this season. You can see the rest of the optimizer's NFL DFS picks here.

How to build Sunday Week 5 NFL DFS lineups

The optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer's NFL DFS picks, at SportsLine

So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.