Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. HerbertJustin Herbert | T. HeinickeTaylor Heinicke | |
| Running Back | N. HarrisNajee Harris | O. HamptonOmarion Hampton | |
| Fullback | S. MatlockScott Matlock | — | — |
| Wide Receiver | L. McConkeyLadd McConkey | M. WilliamsMike Williams | |
| Tight End | W. DisslyWill Dissly | T. ConklinTyler Conklin | |
| Left Tackle | R. SlaterRashawn Slater | B. TaylorBranson Taylor | — |
| Center | Z. JohnsonZion Johnson | A. JamesAndre James | — |
| Right Tackle | M. BectonMekhi Becton | J. SalyerJamaree Salyer | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | D. HandDa'Shawn Hand | J. EboigbeJustin Eboigbe | |
| Nose Tackle | T. TartTeair Tart | J. CaldwellJamaree Caldwell | — |
| Right Defensive End | O. OgbonniaOtito Ogbonnia | N. JonesNaquan Jones | |
| Left Inside Linebacker | D. HenleyDaiyan Henley | T. DyeTroy Dye | |
| Right Inside Linebacker | J. ColsonJunior Colson | D. PerrymanDenzel Perryman | |
| Strongside Linebacker | K. MackKhalil Mack | B. DupreeBud Dupree | |
| Weakside Linebacker | T. TuipulotuTuli Tuipulotu | K. KennardKyle Kennard | |
| Right Cornerback | C. HartCam Hart | B. St-JusteBenjamin St-Juste | — |
| Left Cornerback | D. JacksonDonte Jackson | D. LeonardDeane Leonard | |
| Slot Cornerback | T. StillTarheeb Still | J. TaylorJa'Sir Taylor | — |
| Strong Safety | D. JamesDerwin James | T. JeffersonTony Jefferson | |
| Free Safety | A. GilmanAlohi Gilman | E. MoldenElijah Molden |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. ScottJ.K. Scott | — | — |
| Kicker | C. DickerCameron Dicker | — | — |
| Long Snapper | J. HarrisJosh Harris | — | — |
| Holder | J. ScottJ.K. Scott | — | — |
| Punt Returner | D. DavisDerius Davis | L. McConkeyLadd McConkey | |
| Kick Returner | D. DavisDerius Davis | H. HaskinsHassan Haskins |