Preseason
| WK | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 1 | Aug 9, 2025 | vs | — | Levi's Stadium | ||
| 2 | Aug 16, 2025 | @ |
NFL+
| Allegiant Stadium | ||
| 3 | Aug 23, 2025 | vs | — | Levi's Stadium |
Regular season
| Wk | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 1 | Sep 7, 2025 | @ |
FOX
| Lumen Field | ||
| 2 | Sep 14, 2025 | @ |
FOX
| Caesars Superdome | ||
| 3 | Sep 21, 2025 | vs |
FOX
| Levi's Stadium | ||
| 4 | Sep 28, 2025 | vs |
FOX
| Levi's Stadium | ||
| 5 | Oct 2, 2025 | @ |
AMZN
| SoFi Stadium | ||
| 6 | Oct 12, 2025 | @ | Raymond James Stadium | |||
| 7 | Oct 19, 2025 | vs |
NBC
| Levi's Stadium | ||
| 8 | Oct 26, 2025 | @ |
FOX
| NRG Stadium | ||
| 9 | Nov 2, 2025 | @ | MetLife Stadium | |||
| 10 | Nov 9, 2025 | vs |
FOX
| Levi's Stadium | ||
| 11 | Nov 16, 2025 | @ |
FOX
| State Farm Stadium | ||
| 12 | Nov 24, 2025 | vs |
ESPN
| Levi's Stadium | ||
| 13 | Nov 30, 2025 | @ | Huntington Bank Field | |||
| 14 | — |
BYE
| — | — | — | — |
| 15 | Dec 14, 2025 | vs |
FOX
| Levi's Stadium | ||
| 16 | Dec 22, 2025 | @ |
ESPN
| Lucas Oil Stadium | ||
| 17 | Dec 28, 2025 | vs |
NBC
| Levi's Stadium | ||
| 18 | Jan 4, 2026 | vs | — | Levi's Stadium |
